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Related Experiment Video

Updated: Jun 8, 2026

Monitoring Acupuncture Effects on Human Brain by fMRI
09:55

Monitoring Acupuncture Effects on Human Brain by fMRI

Published on: April 8, 2010

Different brain network activations induced by modulation and nonmodulation laser acupuncture.

Chang-Wei Hsieh1, Jih-Huah Wu, Chao-Hsien Hsieh

  • 1Department of Photonic and Communication Engineering, Asia University, Taichung 41354, Taiwan.

Evidence-Based Complementary and Alternative Medicine : Ecam
|October 19, 2010
PubMed
Summary

This study compared low-level laser acupuncture using continued wave (CW) and 10 Hz-modulated wave (MW) stimulation. Both methods activated distinct brain regions involved in memory and attention, suggesting varied mechanisms beyond sensory processing.

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Area of Science:

  • Neuroscience
  • Medical Imaging
  • Acupuncture Research

Background:

  • Low-level laser acupuncture is a therapeutic modality.
  • Understanding its neurobiological mechanisms is crucial for optimizing treatment.
  • Distinct stimulation parameters may yield different cerebral responses.

Purpose of the Study:

  • To compare cerebral activation patterns between continued wave (CW) and 10 Hz-modulated wave (MW) laser acupuncture.
  • To investigate the neuroimaging mechanism of laser acupuncture at the Yongquan (K1) acupoint.
  • To differentiate the brain responses to CW and MW laser acupuncture.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was employed to assess brain activity.
  • 12 healthy volunteers received either CW or MW laser acupuncture at the left K1 acupoint.

Related Experiment Videos

Last Updated: Jun 8, 2026

Monitoring Acupuncture Effects on Human Brain by fMRI
09:55

Monitoring Acupuncture Effects on Human Brain by fMRI

Published on: April 8, 2010

  • Random-effect (RFX) analysis was used for multisubject data analysis.

    • Main Results:

    • CW stimulation activated the left parietal lobe (inferior parietal lobule, somatosensory cortex, precuneus) and frontal gyrus.
    • MW stimulation activated the left motor cortex, middle temporal gyrus, and bilateral cuneus.
    • Neither CW nor MW stimulation showed activation in placebo groups, with most activated areas linked to memory, attention, and self-consciousness.

    Conclusions:

    • Different laser acupuncture stimulation modes (CW vs. MW) induce distinct cerebral hemodynamic responses.
    • The mechanism of laser acupuncture involves more than just afferent sensory processing.
    • External stimulation alters hemodynamic properties, contributing to the therapeutic effects of laser acupuncture.