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Antitumor agents, 116. Cytotoxic triterpenes from Maytenus diversifolia
H Nozaki1, Y Matsuura, S Hirono
1Division of Medicinal Chemistry and Natural Products, School of Pharmacy, University of North Carolina, Chapel Hill 27599.
Journal of Natural Products
|July 1, 1990
Abstract:
The known triterpenes 3-oxofriedelan-29-oic acid [1], 3-oxofriedelan-28-oic acid [2], and 28,29-dihydroxyfriedelan-3-one [3] have been isolated from Maytenus diversifolia. Compounds 1-3 demonstrated cytotoxicity against the A-549 lung carcinoma cells with ED50 values of 0.21, 1.18, and 0.64 micrograms/ml, respectively.