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Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...

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Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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BDNF Val66Met polymorphism and brain volumes in multiple sclerosis.

D Dinacci1, A Tessitore, A Russo

  • 1Department of Neurological Science, Second University of Naples, Piazza Miraglia 2, 80131, Naples, Italy. daria.3@libero.it

Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
|October 19, 2010
PubMed
Summary

The brain-derived neurotrophic factor (BDNF) Val66Met polymorphism may protect against multiple sclerosis (MS). The Met allele is linked to reduced brain atrophy in MS patients, suggesting a potential protective role.

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Area of Science:

  • Neuroscience
  • Genetics
  • Neurology

Background:

  • Brain-derived neurotrophic factor (BDNF) plays a crucial role in central nervous system (CNS) physiological and pathological processes.
  • Understanding genetic factors influencing multiple sclerosis (MS) is vital for disease management and therapeutic development.

Purpose of the Study:

  • To investigate the association between the BDNF Val66Met polymorphism and clinical and MRI markers of disease activity in MS patients.
  • To explore the potential protective role of the BDNF Met allele against brain atrophy in MS.

Main Methods:

  • Genotyping of the BDNF Val66Met polymorphism in 45 MS patients and 34 healthy controls (HCs).
  • Clinical-MRI examinations to assess global white matter fraction (gWM-f), gray matter fraction (GM-f), cerebrospinal fluid fraction (CSF-f), and abnormal white matter fraction (aWM-f).
  • Statistical analysis including regression to identify associations between genotype, clinical markers, and MRI measures.

Main Results:

  • Val/Val genotype MS patients exhibited lower GM-f and higher CSF-f compared to Val/Val HCs.
  • No statistically significant differences were observed between Val/Met MS patients and HCs.
  • Regression analysis indicated that the Val/Met genotype and a higher number of relapses were associated with lower CSF-f.

Conclusions:

  • The BDNF Met allele may confer a protective effect against MS.
  • The Val66Met polymorphism is associated with brain atrophy markers in MS, with the Met allele potentially mitigating disease-related changes.