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Parathyroid hypertensive factor.

P K Pang1, R Z Lewanczuk, C G Benishin

  • 1Department of Physiology, University of Alberta, Edmonton, Canada.

Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension
|December 1, 1990
PubMed
Summary

A novel parathyroid hypertensive factor (PHF) causes hypertension in rats and humans by increasing calcium uptake in blood vessels. This factor originates in the parathyroid gland and is linked to salt-sensitive hypertension.

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Area of Science:

  • Cardiovascular Research
  • Endocrinology
  • Hypertension Pathophysiology

Background:

  • A circulating hypertensive factor, parathyroid hypertensive factor (PHF), is present in spontaneously hypertensive rats (SHR) but not normotensive rats.
  • PHF induces a delayed increase in blood pressure and vascular calcium uptake, inhibited by calcium antagonists.

Purpose of the Study:

  • To investigate the origin, mechanism of action, and clinical relevance of parathyroid hypertensive factor (PHF).
  • To explore the role of PHF in different models of hypertension, including human studies.

Main Methods:

  • Assessed blood pressure changes and vascular calcium uptake in response to PHF in rat models.
  • Utilized parathyroidectomy and transplant experiments to determine PHF origin.
  • Cultured parathyroid glands to identify PHF production.

Related Experiment Videos

  • Examined parathyroid glands for novel cell types in SHR.
  • Analyzed plasma PHF levels and hypertension in hyperparathyroid patients.

    • Main Results:

    • PHF administration caused a delayed increase in blood pressure and enhanced calcium uptake in rat arteries.
    • Parathyroid glands, particularly a novel cell type in SHR, were identified as the source of PHF.
    • Plasma PHF levels correlated with blood pressure and were found in hyperparathyroid patients.
    • Hypertension and PHF resolved in patients after parathyroidectomy.
    • PHF was associated with low/normal renin and salt-sensitive hypertension.

    Conclusions:

    • The parathyroid gland produces a novel hypertensive factor (PHF) implicated in salt-sensitive hypertension.
    • PHF's mechanism involves increased vascular calcium uptake, suggesting it as a therapeutic target.
    • PHF plays a role in both animal models and human hypertension, particularly in hyperparathyroid states.