Gas-diffusion microextraction
Related Experiment Video
Updated: Jun 8, 2026

Fizzy Extraction of Volatile Organic Compounds Combined with Atmospheric Pressure Chemical Ionization Quadrupole Mass Spectrometry
Published on: July 14, 2017
João Grosso Pacheco1, Inês Maria Valente, Luís Moreira Gonçalves
1REQUIMTE, Chemistry and Biochemistry Department, Faculty of Sciences, University of Porto, Porto, Portugal.
Abstract:
Gas-diffusion microextraction (GDME) is an innovative technique that combines the advantages of membrane-aided gas-diffusion with microextraction concepts. GDME makes uses of a novel portable and low-cost device that comprises a small, commercially available, semi-permeable membrane. Furthermore, if derivatization is integrated into the GDME concept, considerable enrichment factors can be obtained. It may become a powerful tool for any analyst who intends to quantify volatile and semi-volatile analytes in various kinds of matrices. The analysis of vicinal diketones in beer was used as a case study to show GDME applicability and capabilities. Vicinal diketones were derivatized with o-phenylenediamine and then determined by HPLC-UV. Obtained results showed good repeatability and precision with extraction periods at the minute time span.
Related Concept Videos
Gas Chromatography: Introduction
In GC, a sample is vaporized and mixed with an inert carrier gas (the mobile phase), which transports it through a column.
Gas Chromatography–Mass Spectrometry (GC–MS)
A gas chromatograph consists of a long, narrow capillary column with a polysiloxane coating on the inner wall. The coating...
Gas Chromatography: Sample Injection Systems
Two primary injection methods are used...
Behavior of Gas Molecules: Molecular Diffusion, Mean Free Path, and Effusion
Gas Exchange and Transport
Gas Chromatography: Types of Detectors-II

