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[Historical aspect of molecular-targeted therapy for cancer]

Saburo Sone1, Kenji Otsuka, Makoto Tobiume

  • 1Department of Respiratory Medicine and Rheumatology, Institute of Health Biosciences, The University of Tokushima Graduate School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|October 20, 2010
PubMed

Insights

Recent advances in molecularly targeted cancer therapies have improved patient outcomes. This review covers the historical progress in developing these targeted drugs and biomarkers for personalized medicine.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Context:

  • Discovery of critical molecules driving cancer progression.
  • Development of targeted therapies like monoclonal antibodies and small molecules.
  • 15 years of progress in target-specific therapeutics.

Purpose:

  • Review the historical development of molecular-targeted drugs.
  • Discuss the role of biomarkers in patient selection.
  • Highlight progress in personalized cancer medicine.

Summary:

  • Target-directed therapies have significantly improved clinical outcomes for cancer patients.
  • Understanding drug resistance mechanisms is crucial.
  • Biomarkers enhance patient selection for targeted treatments.

Impact:

  • Advances in personalized medicine for cancer treatment.
  • Improved patient selection for molecular-targeted therapy.
  • Enhanced clinical outcomes in various malignancies.

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