Related Experiment Video
Updated: Jun 8, 2026

Cell-based Assay to Study Antibody-mediated Tau Clearance by Microglia
Published on: November 9, 2018
[Molecular targeted therapy in Alzheimer disease]
Yuichi Morohashi1, Taisuke Tomita, Takeshi Iwatsubo
1Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, The University of Tokyo.
Abstract:
Alzheimer disease(AD) is the most common cause of dementia in the elderly. However, the availability of effective disease-modifying drugs for AD is currently limited. Thus, with the aging of the population, the mechanism-based therapeutics for AD is desperately needed. This article will discuss the recent advances of the development of drugs based on "amyloid hypothesis", and the results of clinical trials. The inhibitors or modulators targeting beta- and gamma-secretases that are responsible enzymes for the generation of amyloid-beta peptide(Abeta) deposited in the Abeta brain, or Abeta immunotherapy using anti-Abeta antibodies, are promising candidates. Finally potential mechanism-based adverse effects of these treatments and the strategies to tackle these problems will be discussed.
Related Concept Videos
Alzheimer's Disease: Treatment
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Alzheimer Disease ll: Pathophysiology
Alzheimer Disease l: Introduction
Targeted Cancer Therapies
There are several types of targeted therapies against specific...
Dementia l: Introduction