Related Experiment Video

Updated: Jun 25, 2026

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors
14:39

A Quantitative Assay for Insulin-expressing Colony-forming Progenitors

Published on: November 28, 2011

[The distribution of insulin-containing cells in the developing tissues of the common frog (Rana temporaria)]

A V Dobriakova, E A Shubnikova, L S Pogodina

    Ontogenez
    |November 1, 1990
    PubMed

    Keywords:
    Endocrine SystemRana temporariaDevelopmental BiologyHormonal Signaling

    More Related Videos

    Reproductive Techniques for Ovarian Monitoring and Control in Amphibians04:37

    Reproductive Techniques for Ovarian Monitoring and Control in Amphibians

    Published on: May 12, 2019

    Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay08:34

    Precise Visualization of Insulin Receptors A and B in Murine Brain with an RNA In Situ Hybridization Assay

    Published on: July 15, 2025

    Related Concept Videos

    Insulin Secretory Vesicles01:05

    Insulin Secretory Vesicles

    Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
    Tissue Renewal without Stem Cells01:23

    Tissue Renewal without Stem Cells

    After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
    However, failure of such a system...
    Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

    Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

    The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
    Insulin and C-peptide are co-secreted in...
    Insulin: The Receptor and Signaling Pathways01:28

    Insulin: The Receptor and Signaling Pathways

    Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but this inhibition is released...