Tumor therapy with Amanita phalloides (death cap): stabilization of B-cell chronic lymphatic leukemia

Molecular events that cause tumor formation upregulate a number of HOX genes, called switch genes, coding for RNA polymerase II transcription factors. Thus, in tumor cells, RNA polymerase II is more active than in other somatic cells. Amanita phalloides contains amanitin, inhibiting RNA polymerase II. Partial inhibition with amanitin influences tumor cell--but not normal cell--activity.

To widen the treatment spectrum, homeopathic dilutions of Amanita phalloides, containing amanitin, were given to a patient with leukemia. Monitoring the leukemic cell count, different doses of amanitin were given.

The former duplication time of leukemic cells was 21 months. Within a period of 21 months, the cell count is stabilized to around 10(5)/μL. No leukemia-associated symptoms, liver damage, or continuous erythrocyte deprivation occur.

This new principle of tumor therapy shows high potential to provide a gentle medical treatment.