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AA type renal amyloidosis secondary to FMF: a long-term follow-up in two patients

Aysun Aybal Kutlugün1, Tolga Yildirim, Mahmut Altindal

  • 1Department of Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey. draysunaybal@yahoo.com

Renal Failure
|October 20, 2010
PubMed

Insights

Familial Mediterranean fever (FMF) patients with amyloidosis-induced nephrotic syndrome achieved complete remission with long-term colchicine treatment. This case series reports the longest follow-up without proteinuria in FMF renal amyloidosis.

Area of Science:

  • Nephrology
  • Rheumatology
  • Genetics

Background:

  • Renal amyloidosis is a severe complication of Familial Mediterranean Fever (FMF), often leading to end-stage renal disease.
  • Nephrotic syndrome in FMF patients typically indicates advanced amyloidosis and carries a poor prognosis.

Observation:

  • Two patients with FMF-induced renal amyloidosis and nephrotic syndrome were treated with colchicine.
  • The treatment regimen involved a daily dose of 1.5 mg of colchicine.

Findings:

  • Both patients achieved complete remission of nephrotic syndrome, evidenced by the resolution of proteinuria.
  • The patients maintained a stable clinical course with no proteinuria for over 30 years, representing the longest reported follow-up.

Implications:

  • Long-term colchicine therapy can induce sustained remission in FMF-associated nephrotic syndrome and renal amyloidosis.
  • These findings highlight the efficacy of colchicine in managing severe renal complications of FMF, potentially altering the disease's long-term trajectory.

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