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Exploring Sequence Space to Identify Binding Sites for Regulatory RNA-Binding Proteins

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Auraptene: a natural biologically active compound with multiple targets.

Salvatore Genovese¹, Francesco Epifano

¹Dipartimento di Scienze del Farmaco, Università G. D'Annunzio di Chieti-Pescara, Via dei Vestini 31, Chieti Scalo (CH), Italy. s.genovese@unich.it

Current Drug Targets

|October 20, 2010

Summary

Auraptene, a natural compound from Rutaceae plants, shows significant medicinal potential. This review details its cancer chemopreventive, antimicrobial, and anti-inflammatory effects, highlighting its mechanisms against key biological targets.

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Area of Science:

Natural Product Chemistry
Pharmacology
Medicinal Chemistry

Background:

Auraptene is a prevalent prenyloxycoumarin found in numerous Rutaceae family plants, including edible fruits and vegetables.
Historically known, auraptene has recently gained attention for its diverse pharmacological activities.

Purpose of the Study:

To comprehensively review the reported pharmacological effects of auraptene.
To elucidate the mechanisms of action underlying auraptene's activities by examining its inhibition of key biological targets.

Main Methods:

Literature survey of scientific articles reporting on auraptene.
Analysis of studies detailing auraptene's interactions with biological targets such as metalloproteinases, glycoprotein P, and PPARs.

Main Results:

Auraptene exhibits significant potential as an orally active agent for cancer chemoprevention.
Documented activities include antimicrobial, anti-protozoal, anti-fungal, anti-inflammatory, and antioxidant properties.
Auraptene acts as an inhibitor of critical biological targets, contributing to its observed pharmacological effects.

Conclusions:

Auraptene is a promising natural compound with a wide spectrum of valuable pharmacological activities.
Further research into auraptene's mechanisms of action can unlock its therapeutic potential in various diseases.