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Structural modeling studies of aldehyde dehydrogenase X: insights into key interactions in the tetrameric assembly of

Ghosia Lutfullah1, Natasha Qaisar Khan, Farhat Amin

  • 1Centre of Biotechnology, University of Peshawar, Peshawar, Pakistan. ghosia_lutfullah@yahoo.com

Protein and Peptide Letters
|October 20, 2010
PubMed

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Cooperative Allosteric Transitions01:58

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Cooperative allosteric transitions can occur in multimeric proteins, where each subunit of the protein has its own ligand-binding site. When a ligand binds to any of these subunits, it triggers a conformational change that affects the binding sites in the other subunits; this can change the affinity of the other sites for their respective ligands. The ability of the protein to change the shape of its binding site is attributed to the presence of a mix of flexible and stable segments in the...
Cooperative Allosteric Transitions01:58

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