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Related Experiment Video

Updated: Jun 8, 2026

Effect of Hyaluronic Acid 35 kDa on an In Vitro Model of Preterm Small Intestinal Injury and Healing Using Enteroid-Derived Monolayers
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Published on: July 28, 2022

Why are they having infant colic? A nested case-control study.

S Songül Yalçin1, Emel Orün, Banu Mutlu

  • 1Department of Pediatrics, Hacettepe University Medical School, Ankara, Turkey. siyalcin@hacettepe.edu.tr

Paediatric and Perinatal Epidemiology
|October 20, 2010
PubMed
Summary

Infant colic is linked to maternal factors like lower education, smoking, and psychological distress. Colic may also negatively impact infant growth and sleep patterns up to 8 months.

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Published on: November 30, 2021

Area of Science:

  • Pediatrics
  • Maternal Health
  • Infant Development

Background:

  • Infant colic is a common but poorly understood condition.
  • Identifying risk factors and long-term effects is crucial for infant well-being.

Purpose of the Study:

  • To analyze infant and environmental risk factors for infant colic.
  • To track physical growth and sleeping patterns of colicky infants up to 8 months.

Main Methods:

  • A nested case-control study involving 660 mothers and their infants.
  • Infants diagnosed with colic (47) and non-colic (142) were assessed at 40-55 days and 7-8 months.
  • Maternal questionnaires covered demographics, psychological status, and infant feeding.

Main Results:

  • Colic associated with less educated, smoking mothers, domestic violence, and impaired mother-infant bonding.
  • Mothers of colicky infants reported higher depression, hostility, and irregular sleep.
  • Colicky infants were shorter at 7-8 months and had disrupted sleep patterns.

Conclusions:

  • Perinatal factors including maternal education, smoking, and domestic violence are associated with infant colic.
  • Infant colic may have lasting effects on sleep and physical growth.