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Published on: May 18, 2018
Histological changes in patients with chronic upper gastrointestinal ischaemia
Désirée Van Noord1, Katharina Biermann, Leon Mg Moons
1Departments of Gastroenterology and Hepatology Pathology Intervention Radiology Vascular Surgery Internal Medicine, Erasmus MC - University Medical Center, Rotterdam, the Netherlands. d.vannoord@erasmusmc.nl
Histopathology
|October 20, 2010
Summary
Diagnosing chronic upper gastrointestinal ischaemia (CUGI) is difficult. While histology isn't definitive, reactive gastropathy signs in biopsies can support CUGI diagnosis.
Area of Science:
- Gastroenterology
- Pathology
- Vascular Medicine
Background:
- Chronic upper gastrointestinal ischaemia (CUGI) diagnosis is challenging.
- Current diagnostic methods lack established histological criteria for transient CUGI.
- Understanding gastrointestinal histology in CUGI patients is limited.
Purpose of the Study:
- To investigate upper gastrointestinal histology in patients with confirmed CUGI.
- To determine the role of biopsy analysis in diagnosing CUGI.
- To identify potential histological markers associated with CUGI.
Main Methods:
- Prospective study of patients with suspected CUGI.
- Diagnostic work-up included upper endoscopy, tonometry, and angiography (CT/MR).
- Biopsy samples from duodenum and stomach were analyzed using established classifications (Sydney, Vienna, Chiu, Marsh, OLGA) for gastropathy.
Main Results:
- 79 patients were analyzed; 41 (52%) were diagnosed with CUGI.
- A higher prevalence of gastropathy was observed in patients with CUGI (P=0.025).
- No other significant histological differences were found between CUGI and non-CUGI groups.
Conclusions:
- Histological examination of biopsy samples is not definitive for diagnosing CUGI.
- The presence of reactive gastropathy on histology can serve as supportive evidence for a clinical CUGI diagnosis.
- Further research may refine the role of histology in CUGI work-up.
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