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Updated: Jun 7, 2026

An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells
Published on: July 20, 2014
[Expression of E-cadherin and its clinical significance in non-small cell lung cancer]
1Department of Respiratory Medicine , The Second Affiliated Hospital , Xi'an Medical University , Xi'an , Shanxi 710004 , P. R. China.
Background:
To investigate the expression and clinical significance of E-cadherin (E-Cad) in non-small cell lung cancer (NSCLC) and its metastatic lymph nodes.
Methods:
E-Cad expression was detected in 30 normal lung tissues , 61 cancerous tissues and 41 metastatic lymph nodes by immunohistochemical method.
Results:
In all of the normal epithelial cells , expression of E-Cad was clearly evident on cell-cell boundaries. Abnormal expression rate of E-Cad in primary NSCLC and metastatic lymph nodes were 52. 46 % and 63. 41 % respectively , and no significant difference was found between the two groups ( P > 0. 05) . The abnormal E-Cad expression in lung cancer was closely related to the P-TNM stages , pathological grades and lymph node involvement ( P < 0. 001-0. 05) , but not to the histological classification of the cancer ( P > 0. 05) .
Conclusions:
E-Cad might be a valuable marker in assessing biological behavior and metastatic potential of NSCLC.
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