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Proteomics

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
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Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

Cancer-Critical Genes I: Proto-oncogenes

Cancer-Critical Genes I: Proto-oncogenes

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Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

mTOR Signaling and Cancer Progression

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The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
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mTOR Signaling and Cancer Progression

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Related Experiment Video

Updated: Jun 7, 2026

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification

Published on: November 15, 2017

Oncoproteomics.

S Joshi¹, A K Tiwari, B Mondal

¹Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198-5870, USA.

Clinica Chimica Acta; International Journal of Clinical Chemistry

|October 20, 2010

Summary

This summary is machine-generated.

Cancer proteomics, or oncoproteomics, identifies cancer-causing gene and protein changes. This field aims to integrate proteomic technologies into clinical practice for improved cancer diagnosis, prognosis, and treatment strategies.

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Area of Science:

Oncoproteomics
Molecular Biology
Cancer Research

Background:

Cancer development is linked to genetic alterations and aberrant protein functions.
Understanding gene-protein interactions in cellular signaling is crucial for cancer research.
Aberrant signaling pathways driven by protein molecules are fundamental to cancer etiology.

Purpose of the Study:

To review recent advances in proteomic research strategies for cancer.
To highlight the application of oncoproteomics in discovering novel tumor markers and drug targets.
To elucidate the role of proteomics in understanding biomarker action and anticancer drug mechanisms, including drug resistance.

Main Methods:

Proteomic research strategies
Analysis of tumor-specific proteomic profiles
Biomarker discovery and validation

Main Results:

Proteomics offers insights into gene-protein interactions and molecular pathways in cancer.
Oncoproteomics facilitates the identification of novel diagnostic and prognostic markers.
Proteomic data aids in understanding tumor development and identifying therapeutic targets.

Conclusions:

Oncoproteomics holds significant potential to revolutionize cancer research and patient care.
Integration of proteomic technologies in clinical labs can enhance cancer diagnosis, prognosis, and treatment assessment.
Further research in oncoproteomics will lead to improved understanding and management of cancer.