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Related Experiment Video

Updated: Jun 7, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

Published on: May 31, 2017

Healing genes in the nervous system.

Xandra O Breakefield¹, Miguel Sena-Esteves

¹Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. breakefield@hms.harvard.edu

|October 20, 2010

Summary

Gene therapy offers new treatments for nervous system diseases. This review covers delivery methods, preclinical strategies, clinical challenges, and ethical issues in gene therapy.

Area of Science:

Neuroscience
Genetics
Biotechnology

Background:

Gene therapy is an evolving field with significant potential for treating neurological disorders.
Advances in genetic engineering have paved the way for novel therapeutic strategies.

Purpose of the Study:

To provide an overview of gene therapy delivery vehicles for nervous system diseases.
To discuss preclinical strategies and clinical limitations of current gene therapy approaches.
To address the ethical considerations surrounding gene therapy applications.

Main Methods:

Review of current literature on gene therapy delivery systems.
Analysis of preclinical studies targeting neurological diseases.
Examination of clinical trial data and ethical frameworks.

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Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

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Last Updated: Jun 7, 2026

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

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Published on: May 31, 2017

Genetic Study of Axon Regeneration with Cultured Adult Dorsal Root Ganglion Neurons

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Published on: August 17, 2012

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Main Results:

Various delivery vehicles are available for gene therapy, each with specific advantages and disadvantages.
Preclinical strategies show promise for treating major nervous system diseases.
Significant clinical limitations and ethical considerations need to be addressed for widespread adoption.

Conclusions:

Gene therapy holds great promise for treating neurological conditions.
Further research and ethical deliberation are crucial for advancing gene therapy applications in the nervous system.