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Management of bisphosphonate-associated osteonecrosis: pentoxifylline and tocopherol in addition to antimicrobial
Matthew S Epstein1, Fredrick W Wicknick, Joel B Epstein
1University of Washington, Seattle, WA, USA.
Background:
Studies of the use of pentoxifylline and α-tocopherol in osteoradionecrosis of the jaw have suggested their efficacy in this condition. We report an initial case series of pentoxifylline and α-tocopherol for patients with bisphosphonate-associated osteonecrosis (BON).
Methods:
Six cases referred for management of BON were provided pentoxifylline and α-tocopherol in addition to antimicrobial therapy, and followed for a mean of 10 months.
Results:
A 74% decrease in area of bony exposure and symptom control was achieved in these cases.
Discussion:
Pentoxifylline with α-tocopherol may represent a strategy for management of BON. Controlled trials in cases of BON appear warranted.
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