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Related Experiment Video

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Co-analysis of Brain Structure and Function using fMRI and Diffusion-weighted Imaging
17:06

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Published on: November 8, 2012

White matter maturation reshapes structural connectivity in the late developing human brain.

P Hagmann1, O Sporns, N Madan

  • 1Department of Radiology, University Hospital Center and University of Lausanne, 1011 Lausanne, Switzerland. patric.hagmann@epfl.ch

Proceedings of the National Academy of Sciences of the United States of America
|October 20, 2010
PubMed
Summary
This summary is machine-generated.

Brain white matter maturation refines neural networks from childhood to adolescence. This study shows increasing structural and functional connectivity, enhancing overall brain efficiency and synchrony with age.

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Area of Science:

  • Neuroscience
  • Developmental Neuroscience
  • Neuroimaging

Background:

  • The human brain undergoes significant functional development from childhood to adolescence.
  • White matter maturation, including myelination and axonal changes, is crucial for this functional refinement.
  • Understanding the interplay between structural and functional connectivity is key to mapping brain development.

Purpose of the Study:

  • To investigate the contribution of white matter maturation to brain connectivity development in individuals aged 2 to 18 years.
  • To analyze changes in network topology and connection efficacy during this developmental period.
  • To examine the relationship between structural and functional connectivity and its age-dependent strengthening.

Main Methods:

  • High b-value diffusion MRI tractography and connectivity analysis were used to measure white matter changes.
  • Connection efficacy was quantified as the inverse of average diffusivity along fiber tracts.
  • Resting-state functional MRI was employed to assess functional connectivity in a subset of participants.

Main Results:

  • Significant refinement in network topology was observed, with increased node strength and efficiency, and decreased clustering.
  • Core structural modules and hubs were established early and strengthened throughout development.
  • A positive correlation between structural and functional connectivity was confirmed, strengthening with age.

Conclusions:

  • White matter maturation drives network refinement, leading to increased global brain efficiency through enhanced integration and reduced segregation.
  • The strengthening correlation between structural and functional connectivity highlights the critical role of white matter development in achieving brain-wide coherence and synchrony.