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Updated: Jun 7, 2026

Production and Testing of Antimicrobial Peptides and Their Mimics
Published on: April 10, 2026
Short alkylated peptoid mimics of antimicrobial lipopeptides
Nathaniel P Chongsiriwatana1, Tyler M Miller, Modi Wetzler
1Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois 60208, USA.
Abstract:
We report the creation of alkylated poly-N-substituted glycine (peptoid) mimics of antimicrobial lipopeptides with alkyl tails ranging from 5 to 13 carbons. In several cases, alkylation significantly improved the selectivity of the peptoids with no loss in antimicrobial potency. Using this technique, we synthesized an antimicrobial peptoid only 5 monomers in length with selective, broad-spectrum antimicrobial activity as potent as previously reported dodecameric peptoids and the antimicrobial peptide pexiganan.
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