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Related Concept Videos

Osteoclasts in Bone Remodeling01:31

Osteoclasts in Bone Remodeling

Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during bone...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
Hormones and Bone Tissue01:17

Hormones and Bone Tissue

The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Role of Vitamins in Maintaining Bone Health01:25

Role of Vitamins in Maintaining Bone Health

The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...

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Related Experiment Videos

Pemphigus and osteoporosis: a case-control study.

Yonit Wohl1, Jacob Dreiher, Arnon D Cohen

  • 1Sackler School of Medicine, Tel-Aviv University, Tel-Aviv, Israel.

Archives of Dermatology
|October 20, 2010
PubMed
Summary
This summary is machine-generated.

Pemphigus patients have a significantly higher risk of osteoporosis, even after accounting for steroid use. Osteoporosis monitoring and treatment in these patients were found to be suboptimal.

Related Experiment Videos

Area of Science:

  • Dermatology
  • Endocrinology
  • Rheumatology

Background:

  • Pemphigus is an autoimmune blistering disease.
  • Osteoporosis is a skeletal disorder characterized by decreased bone density.
  • Glucocorticosteroid therapy is a common treatment for pemphigus but is also a risk factor for osteoporosis.

Purpose of the Study:

  • To investigate the association between pemphigus and osteoporosis.
  • To assess osteoporosis prevalence in pemphigus patients compared to controls.
  • To evaluate osteoporosis management in pemphigus patients.

Main Methods:

  • A case-control study was conducted using a large Israeli healthcare database.
  • 255 pemphigus patients were compared with 509 age- and sex-matched controls.
  • Data on osteoporosis, bone mineral density scans, and osteoporosis medications were analyzed.

Main Results:

  • Osteoporosis prevalence was 40.4% in pemphigus patients versus 6.5% in controls (OR, 9.77).
  • The association persisted after adjusting for confounders like glucocorticosteroid use (OR, 4.27).
  • Osteoporosis management was suboptimal, with only 70.9% of patients having a bone density test in 10 years and short treatment durations.

Conclusions:

  • An independent association exists between pemphigus and osteoporosis.
  • Glucocorticosteroid use does not fully explain the increased osteoporosis risk in pemphigus patients.
  • Improved monitoring and treatment of osteoporosis in pemphigus patients are warranted.