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Correlation between severity of coronary artery stenosis and perfusion defect assessed by SPECT myocardial perfusion

M M Zaman1, S S Haque, M A Siddique

  • 1Department of Cardiology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbagh, Dhaka, Bangladesh.

Mymensingh Medical Journal : MMJ
|October 20, 2010
PubMed

Insights

Technetium-99m (Tc-99m) tetrofosmin Single Photon Emission Computed Tomography myocardial perfusion imaging (SPECT-MPI) effectively assesses coronary artery stenosis severity. This non-invasive method shows high accuracy comparable to coronary angiography for diagnosing coronary artery disease (CAD).

Area of Science:

  • Cardiology
  • Nuclear Medicine
  • Diagnostic Imaging

Background:

  • Coronary artery disease (CAD) severity assessment relies on various non-invasive techniques.
  • Coronary angiography (CAG) is the gold standard for diagnosing and quantifying coronary artery stenosis.
  • Single Photon Emission Computed Tomography-myocardial perfusion imaging (SPECT-MPI) using Technetium-99m (Tc-99m) tetrofosmin is an established non-invasive tool for CAD assessment.

Purpose of the Study:

  • To evaluate the effectiveness of Tc-99m SPECT-MPI in assessing coronary artery stenosis severity.
  • To compare the diagnostic performance of Tc-99m SPECT-MPI against coronary angiography (CAG).

Main Methods:

  • A prospective observational study involving 82 consecutive patients with suspected CAD.
  • Tc-99m SPECT-MPI performed using a one-day exercise stress and rest protocol.
  • Comparison of SPECT-MPI findings with results from coronary angiography (CAG).

Main Results:

  • SPECT-MPI demonstrated a sensitivity of 87.09% and specificity of 80.95% in detecting coronary artery stenosis.
  • The positive predictive value, negative predictive value, and accuracy were 91.01%, 73.91%, and 85.18%, respectively.
  • A high concordance was observed between SPECT-MPI and CAG in assessing the severity of coronary artery lesions.

Conclusions:

  • Tc-99m SPECT-MPI is a safe, effective, and accurate non-invasive tool for detecting coronary artery stenosis severity.
  • SPECT-MPI can reliably predict the severity of coronary artery disease (CAD), offering a valuable alternative to invasive procedures.

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