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Klinefelter syndrome presenting as behavioral problems in a young adult
Alexandra M Molnar1, Genji S Terasaki, John K Amory
1International Medicine Clinic, Harborview Medical Center, Box 359895, 325 9th Avenue, Seattle, WA 98104, USA. amolnar@u.washington.edu
Background:
An 18-year-old Somali man presented to a primary care clinic to investigate a potential pathophysiological reason for behavioral problems at school that had arisen in the past 1-2 years. A previous physical examination at school revealed the patient to have small, firm testicles which prompted further testing.
Investigation:
Thyroid function and levels of prolactin, total testosterone, follicle-stimulating hormone and luteinizing hormone were determined. Testes were measured. Chromosome analysis testing was performed to determine the patient's karyotype.
Diagnosis:
Klinefelter syndrome with a 47,XXY karyotype.
Management:
Testosterone replacement therapy was recommended, but the patient declined treatment.
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