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Enucleation following treatment with intravenous pentamidine for Acanthamoeba sclerokeratitis
Rebecca A Kuennen1, Reynell Harder Smith, Thomas F Mauger
1Department of Ophthalmology, The Ohio State University, Columbus, Ohio, USA.
Purpose:
To describe the course and outcome of treatment of advanced Acanthamoeba sclerokeratitis with intravenous pentamidine.
Methods:
A case of advanced Acanthamoeba sclerokeratitis was resistant to conventional therapy and was treated with intravenous pentamidine. The eye was later removed due to incapacitating pain.
Results:
The eye showed Acanthamoeba organisms within the cornea and evidence of acute and chronic inflammation throughout the remainder of the eye. The patient has survived without orbital recurrence for 2 years.
Conclusions:
This case demonstrates late inflammation with active Acanthameoba keratitis following systemic pentamidine therapy.
