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Updated: Jun 7, 2026
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Detection of a Circulating MicroRNA Custom Panel in Patients with Metastatic Colorectal Cancer
Published on: March 14, 2019
Biomarkers for colorectal cancer
Takuji Tanaka1, Mayu Tanaka, Takahiro Tanaka
1The Tohkai Cytopathology Institute: Cancer Research and Prevention (TCI-CaRP), 5-1-2 Minami- Uzura, Gifu 500-8285, Japan.
International Journal of Molecular Sciences
|October 20, 2010
Summary
Early detection of colorectal cancer (CRC) is crucial for reducing mortality. Novel non-invasive biomarkers are needed to improve upon current screening methods like colonoscopy and fecal occult blood tests.
Area of Science:
- Oncology
- Biomarker Discovery
- Cancer Screening
Background:
- Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally.
- Early detection of precancerous lesions through regular screening can significantly reduce CRC incidence and mortality.
- Current screening methods like colonoscopy are effective but invasive and costly, highlighting the need for alternatives.
Purpose of the Study:
- To address the limitations of existing colorectal cancer screening methods.
- To explore the potential of novel non-invasive biomarkers for early CRC detection.
- To identify genetic, epigenetic, or protein markers in stool or serum for improved CRC diagnosis.
Main Methods:
- Review of validation studies evaluating various biomarkers for CRC detection.
- Analysis of current non-invasive screening techniques, including fecal occult blood tests.
- Exploration of advancements in genomics and proteomics for biomarker discovery.
Main Results:
- Colonoscopy improves CRC detection rates but presents challenges in cost and convenience.
- Existing non-invasive methods like fecal occult blood tests are widely used but have limitations.
- Ongoing research focuses on genetic, epigenetic, and protein markers for non-invasive CRC screening.
Conclusions:
- There is a significant need for accessible and non-invasive biomarkers for early colorectal cancer detection.
- Advances in molecular biology offer promising avenues for discovering novel biomarkers.
- Future research in genomics and proteomics is expected to yield improved non-invasive screening tools for CRC.
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