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Updated: Jun 7, 2026

A Gradient-generating Microfluidic Device for Cell Biology
11:05

A Gradient-generating Microfluidic Device for Cell Biology

Published on: August 30, 2007

Biological applications of microfluidic gradient devices.

Sudong Kim1, Hyung Joon Kim, Noo Li Jeon

  • 1School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744, Korea.

Integrative Biology : Quantitative Biosciences From Nano to Macro
|October 20, 2010
PubMed
Summary

Microfluidic devices create precise molecular gradients, crucial for studying cell behaviors like immune response and cancer. These tools enable quantitative analysis of cellular environments, advancing our understanding of biological processes.

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Developmental Biology

Background:

  • Molecular gradients are vital in physiological and pathological processes, including immune response, wound healing, development, and cancer metastasis.
  • Engineering tools have advanced the creation of experimental platforms for quantitative cellular microenvironment characterization.
  • Recent developments focus on microfluidics for precise control over cellular environments.

Purpose of the Study:

  • To review the emergence and applications of microfluidics-based gradient generators.
  • To highlight their role in understanding fundamental biological processes.
  • To discuss manipulation of spatial and temporal signaling molecule distribution.

Main Methods:

  • Review of microfluidics-based gradient generation techniques.

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Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
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Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

A Microfluidic Device for Studying Multiple Distinct Strains
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A Microfluidic Device for Studying Multiple Distinct Strains

Published on: November 9, 2012

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Last Updated: Jun 7, 2026

A Gradient-generating Microfluidic Device for Cell Biology
11:05

A Gradient-generating Microfluidic Device for Cell Biology

Published on: August 30, 2007

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy
13:10

Creating Adhesive and Soluble Gradients for Imaging Cell Migration with Fluorescence Microscopy

Published on: April 4, 2013

A Microfluidic Device for Studying Multiple Distinct Strains
08:15

A Microfluidic Device for Studying Multiple Distinct Strains

Published on: November 9, 2012

  • Discussion of applications in 2D and 3D cellular microenvironments.
  • Emphasis on methods for controlling signaling molecule distribution.

    • Main Results:

    • Microfluidic gradient generators offer quantitative and reproducible characterization of cellular responses.
    • These platforms enhance the study of chemotaxis and morphogenesis.
    • Advanced techniques allow precise manipulation of molecular gradients in cellular contexts.

    Conclusions:

    • Microfluidics provides powerful tools for dissecting the role of molecular gradients in biology.
    • This technology facilitates a deeper understanding of cell behavior and disease mechanisms.
    • Future research can leverage these platforms for novel therapeutic and diagnostic strategies.