Diffusively coupled bursters: effects of cell heterogeneity
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Updated: Jun 7, 2026

Heteromulticellular Stromal Cells in Scaffold-free 3D Cultures of Epithelial Cancer Cells to Drive Invasion
Published on: April 4, 2025
G De Vries1, A Sherman, H R Zhu
1Mathematical Research Branch,NIDDK, National Institutes of Health,Bethesda, MD 20892, USA.
Abstract:
The interaction of a pair of weakly coupled biological bursters is examined.Bursting refers to oscillations in which an observable slowly alternates between phases of relative quiescence and rapid oscillatory behavior. The motivation for this work is to understand the role of electrical coupling in promoting the synchronization of bursting electrical activity (BEA) observed in the -cells of the islet of Langerhans, which secrete insulin in response to glucose. By studying the coupled fast subsystem of a model of BEA, we focus on the interaction that occurs during the rapid oscillatory phase. Coupling is weak, diffusive and non-scalar. In addition,non-identical oscillators are permitted. Using perturbation methods with the assumption that the uncoupled oscillators are near a Hopf bifurcation, a reduced system of equations is obtained. A detailed bifurcation study of this reduced system reveals a variety of patterns but suggests that asymmetrically phase-locked solutions are the most typical. Finally, the results are applied to the unreduced full bursting system and used to predict the burst pattern for a pair of cells with a given coupling strength and degree of heterogeneity.
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