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Updated: Jun 7, 2026
Trophoblast Cell Recovery from Angiogenesis-Tube Formation Assay for Differentiation Marker Expression Analysis
Published on: November 8, 2024
Treating gestational trophoblastic disease
Noah Rodriguez1, Donald P Goldstein, Ross S Berkowitz
1Brigham and Women's Hospital/Dana Farber Cancer Institute, Department of Obstetrics and Gynecology, New England Trophoblastic Disease Center, Harvard Medical School, Boston, MA 02115, USA.
Importance Of The Field:
Gestational trophoblastic disease is one of the few human malignancies that is curable, even in advanced stages of the disease. However, appropriate management and follow-up are essential components in curing this disease.
Areas Covered In This Review:
Observational, retrospective and prospective studies evaluating the efficacy of medical and surgical management of gestational trophoblastic disease were analyzed to provide a comprehensive review of current and new treatment modalities. We searched PubMed, Medline and the Library of Congress from January 1965 to January 2010.
What The Reader Will Gain:
The reader will obtain information on how to classify gestational trophoblastic neoplasia (GTN) into low- and high-risk groups, as well as learn the medical and surgical management of low- and high-risk GTN and recurrent GTN. The effectiveness of treatment regimens and subsequent fertility is also reviewed.
Take Home Message:
GTN is highly responsive to chemotherapy. However, surgery is an important adjunct in select cases. Even in advanced-stage or recurrent disease, cure can be achieved and fertility preserved.
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