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Microwave modified non-crosslinked pectin films with modulated drug release
Nor Khaizan Anuar1, Tin Wui Wong, Mohd Nasir Taib
1Particle Design Research Group, Faculty of Pharmacy, Universiti Teknologi MARA, Selangor, Malaysia.
Pharmaceutical Development and Technology
|October 21, 2010
Summary
Microwave treatment of pectin films containing sulfanilamide, sulfathiazole, and sulfamerazine altered drug release. Increased matrix interaction, not amorphousness, was key to retarding drug release, especially for less soluble drugs.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Drug Delivery
Background:
- Pectin films are utilized for drug delivery due to their biocompatibility and biodegradability.
- Controlling drug release from polymer matrices is crucial for effective therapeutic outcomes.
- Microwave irradiation is an emerging technique for modifying polymer properties.
Purpose of the Study:
- To investigate the impact of microwave irradiation on the drug release characteristics of pectin films.
- To explore the relationship between matrix properties (interaction, crystallinity, amorphousness) and drug release.
- To evaluate the influence of drug solubility on microwave-induced changes in pectin films.
Main Methods:
- Preparation of pectin films containing sulfanilamide, sulfathiazole, and sulfamerazine via solvent evaporation.
- Microwave treatment of films at 80 W for 5-40 minutes.
- Characterization using drug dissolution testing, drug content assay, DSC, XRD, and SEM.
Main Results:
- Microwave treatment increased matrix amorphousness but decreased drug release propensity.
- A stronger matrix interaction was observed post-microwave treatment, correlating with drug release retardation.
- The extent of drug release retardation was greater for sulfanilamide (SN-P) films, indicating solubility dependence.
- Increased amorphous structure did not directly correlate with enhanced drug release.
Conclusions:
- Microwave irradiation can modulate drug release from pectin films by altering matrix interaction.
- The effect of microwave treatment on drug release is dependent on drug solubility and matrix interactions.
- This study suggests a potential method for controlling drug release profiles using microwave technology in pectin-based drug delivery systems.
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