Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Evolutionary Relationships through Genome Comparisons

Evolutionary Relationships through Genome Comparisons

Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...

Gene Evolution - Fast or Slow?

Gene Evolution - Fast or Slow?

The genomes of eukaryotes are punctuated by long stretches of sequence which do not code for proteins or RNAs. Although some of these regions do contain crucial regulatory sequences, the vast majority of this DNA serves no known function. Typically, these regions of the genome are the ones in which the fastest change, in evolutionary terms, is observed, because there is typically little to no selection pressure acting on these regions to preserve their sequences.
In contrast, regions which code...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Expert consensus on clinical application of absorbable polymer screw on foot and ankle surgery].

Zhongguo gu shang = China journal of orthopaedics and traumatology·2026

Same author

Prevalence and plasma exosome-derive microRNA diagnostic biomarker screening of adolescent idiopathic scoliosis in Yunnan Province, China.

Frontiers in pediatrics·2024

Same author

Treatment with bone marrow mesenchymal stem cells combined with plumbagin alleviates spinal cord injury by affecting oxidative stress, inflammation, apoptotis and the activation of the Nrf2 pathway.

International journal of molecular medicine·2016

Same author

Identification of partially linear structure in additive models with an application to gene expression prediction from sequences.

Biometrics·2011

Same author

Improving taxonomy-based protein fold recognition by using global and local features.

Proteins·2011

Same author

An improved classification of G-protein-coupled receptors using sequence-derived features.

BMC bioinformatics·2010

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Constructing consensus genetic maps in comparative analysis.

Xin Chen¹, Jian-Yi Yang

¹Division of Mathematical Sciences, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore. chenxin@ntu.edu.sg

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology

|October 21, 2010

Summary

Constructing accurate consensus genetic maps is challenging. This new comparative approach uses related genomes to resolve conflicts, improving genetic map accuracy over existing methods.

More Related Videos

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

Published on: June 28, 2012

Related Experiment Videos

Last Updated: Jun 7, 2026

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Genetic Mapping of Thermotolerance Differences Between Species of Saccharomyces Yeast via Genome-Wide Reciprocal Hemizygosity Analysis

Published on: August 12, 2019

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

High-throughput Physical Mapping of Chromosomes using Automated in situ Hybridization

Published on: June 28, 2012

Area of Science:

Computational Biology
Genomics
Bioinformatics

Background:

Building consensus genetic maps is complex, often relying solely on individual map marker orders.
Existing methods struggle with ordering conflicts among genetic maps.

Purpose of the Study:

To develop a novel comparative approach for constructing more accurate consensus genetic maps.
To leverage order relations from related genomes to resolve conflicts in individual genetic maps.

Main Methods:

Developed a comparative approach integrating marker order from individual and related genomes.
Implemented the approach as an integer linear programming model.
Validated on simulated and real biological datasets.

Main Results:

The proposed method successfully resolves ordering conflicts among individual genetic maps.
Achieved minimum rearrangement distance to the reference genome while preserving maximum order relations.
Demonstrated superior accuracy in constructing consensus genetic maps compared to the MergeMap approach.

Conclusions:

The comparative approach offers a more accurate method for consensus genetic map construction.
This approach enhances genomic analysis by providing reliable genetic maps.
It sets a new benchmark for computational methods in comparative genomics.