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Reprogramming Pancreatic Ductal Adenocarcinoma to Pluripotency

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The Pancreatic Expression database: 2011 update.

Rosalind J Cutts¹, Emanuela Gadaleta, Stephan A Hahn

¹Centre for Molecular Oncology and Imaging, Institute of Cancer and CR-UK Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK.

Nucleic Acids Research

|October 21, 2010

Summary

This summary is machine-generated.

The Pancreatic Expression database (PED) now offers expanded -omics data and enhanced features for integrated analysis. This resource supports cancer research by enabling data sharing and interoperability.

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Area of Science:

Bioinformatics
Genomics
Proteomics

Background:

The Pancreatic Expression database (PED) is a primary resource for pancreatic -omics data.
Recent advancements have significantly increased PED's data content and accessibility.

Purpose of the Study:

To detail the new and improved features of the PED.
To highlight its capabilities for integrative data analysis and its role in cancer research.

Main Methods:

Consolidation of over 60,000 measurements from transcriptomics, proteomics, genomics, and miRNA profiles.
Development of an interface for integrative queries combining PED data with external biological resources (NCBI, Ensembl, UniProt, Reactome).

Main Results:

PED now houses extensive multi-omics data from diverse pancreas studies.
The interface facilitates retrieval and integration of omics, annotation, and clinical data.
PED is integrated into the International Cancer Genome Consortium (ICGC) data portal.

Conclusions:

PED serves as a crucial, expanded resource for pancreatic research.
Enhanced data sharing and interoperability are vital for advancing cancer research.
PED's integration with ICGC promotes collaborative genomic studies.