Related Experiment Video

Updated: Jun 7, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
07:25

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer

Published on: March 6, 2018

Low serum testosterone and increased mortality in men with coronary heart disease

Chris J Malkin1, Peter J Pugh, Paul D Morris

  • 1Department of Cardiology, Royal Hallamshire Hospital, Sheffield, UK

Heart (British Cardiac Society)
|October 21, 2010
PubMed

Insights

Testosterone deficiency is common in men with coronary disease and significantly increases mortality risk. Further research into testosterone replacement therapy is warranted to improve survival outcomes.

Area of Science:

  • Cardiology
  • Endocrinology
  • Men's Health

Background:

  • Coronary disease is a leading cause of mortality.
  • Testosterone deficiency is increasingly recognized as a potential health concern.

Purpose of the Study:

  • To determine the prevalence of testosterone deficiency in men with coronary disease.
  • To investigate the impact of serum testosterone levels on survival in this cohort.

Main Methods:

  • A longitudinal follow-up study was conducted.
  • 930 men with coronary disease were recruited between 2000 and 2002.
  • Follow-up averaged 6.9 years, assessing all-cause and vascular mortality.

Main Results:

  • The prevalence of testosterone deficiency was 20.9% (bio-available testosterone) or 16.9% (total testosterone).
  • Men with testosterone deficiency had significantly higher mortality rates (21% vs. 12%).
  • Low bio-available testosterone was an independent predictor of mortality, alongside left ventricular dysfunction.

Conclusions:

  • Testosterone deficiency is prevalent in men with coronary disease.
  • Low testosterone levels are associated with significantly worse survival outcomes.
  • Prospective trials are needed to evaluate testosterone replacement therapy's effect on survival.
Abstract

Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Disorders of the Male Reproductive System01:20

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
Blood Studies for Cardiovascular System I: Cardiac Biomarkers01:20

Blood Studies for Cardiovascular System I: Cardiac Biomarkers

Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
The essential diagnostic tools for detecting myocardial necrosis and monitoring individuals suspected of having acute coronary syndrome (ACS) include:
Troponins
Troponins, particularly cardiac troponins I and T, are the most precise and sensitive markers of myocardial injury. They are detectable within 4-6 hours of myocardial injury and remain...