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Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Ras Gene02:38

The Ras Gene

The Ras-gene-encoded proteins are regulators of signaling pathways controlling cell proliferation, differentiation, or cell survival. The Ras-gene family in humans constitutes three primary members—the HRas, NRas, and KRas. These genes code for four functionally distinct yet closely related proteins—the HRas, NRas, KRas4A, and KRas4B. The involvement of mutant Ras genes in human cancer was first discovered in 1982 and is among the most common causes of human tumorigenesis.
Ras is a superfamily...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...

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Related Experiment Video

Updated: Jun 7, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
05:36

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

[Hereditary renal cell carcinomas].

A Hartmann1, C G Stöhr, K Junker

  • 1Pathologisches Institut der Universität Erlangen-Nürnberg, Krankenhausstr. 12, 91054, Erlangen. Arndt.Hartmann@uk-erlangen.de

Der Pathologe
|October 21, 2010
PubMed
Summary
This summary is machine-generated.

Hereditary tumor syndromes cause specific renal cell carcinoma types. Recognizing these histopathological features aids in diagnosing genetic causes and exploring new therapeutic options.

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Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers
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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
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Related Experiment Videos

Last Updated: Jun 7, 2026

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane
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Using the Chicken Chorioallantoic Membrane In Vivo Model to Study Gynecological and Urological Cancers
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Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy
11:27

Modeling Spontaneous Metastatic Renal Cell Carcinoma (mRCC) in Mice Following Nephrectomy

Published on: April 29, 2014

Area of Science:

  • Oncology
  • Genetics
  • Pathology

Context:

  • Renal cell carcinomas (RCCs) are linked to several hereditary tumor syndromes.
  • Specific histopathological features of RCCs can indicate an underlying genetic cause.
  • Recent advancements have identified genetic alterations responsible for many hereditary tumor syndromes.

Purpose:

  • To highlight the distinct histopathological appearances of renal cell carcinomas in various hereditary cancer syndromes.
  • To correlate specific tumor types with their associated genetic syndromes.
  • To underscore the diagnostic significance of RCC histology in identifying hereditary conditions.

Summary:

  • Von Hippel-Lindau syndrome (VHL) is associated with clear cell and cystic RCCs.
  • Birt-Hogg-Dubé syndrome presents with oncocytomas and chromophobe RCCs, sometimes as hybrid tumors.
  • Hereditary papillary RCC (HPRC) involves well-differentiated papillary carcinomas (WHO Type 1).
  • Hereditary leiomyomatosis and RCC (HLRCC) is characterized by poorly differentiated papillary RCCs (WHO Type 2), often with leiomyomas/leiomyosarcomas.

Impact:

  • Understanding these associations aids in early diagnosis of hereditary cancer syndromes.
  • Specific tumor subtypes may guide genetic testing and counseling.
  • Identified genetic causes pave the way for targeted therapies and clinical trials for hereditary RCCs.