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Related Concept Videos

Voltage-gated Ion Channels01:26

Voltage-gated Ion Channels

11.0K
Voltage-gated ion channels are transmembrane proteins that open and close in response to changes in the membrane potential. They are present on the membranes of all electrically excitable cells such as neurons, heart, and muscle cells.
Generally, all voltage-gated ion channels have a 'voltage-sensing domain' that spans the lipid bilayer. The charged residues in the sensor move in response to the membrane potential changes that open the channel allowing ions movement. There are several types of...
11.0K
Ion Channels01:19

Ion Channels

91.5K
The movement of ions like sodium, potassium, and calcium into and out of the cell is essential to maintain the electrochemical gradient in living cells. The ion channels—a class of membrane transport proteins—help maintain this ionic gradient for the smooth functioning of physiological activities such as maintaining cell size and volume, conducting nerve impulses, and gas and nutrient exchange.
Ion channels are specialized integral membrane proteins on the plasma membrane that allow...
91.5K
Non-gated Ion Channels01:24

Non-gated Ion Channels

8.3K
Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
Compared to the gated ion channels, the non-gated channels, also known as leakage or passive channels, have no gating mechanism....
8.3K
Mechanically-gated Ion Channels01:12

Mechanically-gated Ion Channels

7.8K
Mechanically-gated ion channels are proteins found in eukaryotic and prokaryotic cell membranes that open in response to mechanical stress. Tension, compression, swelling, and shear stress can alter the conformation of the protein, opening a transmembrane channel that allows the passage of ions for signal transmission. In eukaryotes, mechanically-gated channels are distributed in several regions like the neurons, lungs, skin, bladder, and heart, where they play critical roles in numerous...
7.8K
Ligand-gated Ion Channels01:19

Ligand-gated Ion Channels

14.4K
Ligand-gated ion channels are transmembrane proteins with a channel for ions to pass through and a binding site for a ligand. The channel opens only when a ligand attaches to the binding site.
Three Subfamilies of Ligand-gated Ion Channels
Ligand-gated ion channels fall into three subfamilies. The 'Cys-loop' includes the nicotinic acetylcholine receptors, γ-aminobutyric acid (GABA), glycine, and 5-hydroxytryptamine receptors. The second one is the 'Pore-loop' channels that...
14.4K
G-Protein Gated Ion Channels01:21

G-Protein Gated Ion Channels

5.8K
GPCRs are primarily responsible for our sense of smell, taste, and vision.  The binding of a sensory stimulus activates GPCR to stimulate effector proteins, many of which are ion channels in the sensory organs. GPCRs modulate the opening and closing of the target ion channels either directly by binding them, or by releasing second messengers that activate these channels. As ions move across the membrane, the membrane potential is altered, which induces an appropriate response.
Sensory...
5.8K

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Updated: Feb 10, 2026

Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
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Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches

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Ion channels as antivirus targets.

Xin Liang1, Zhi-Yuan Li

  • 1State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, 510530, China.

Virologica Sinica
|October 21, 2010
PubMed
Summary

Viral ion channels are crucial for virus life cycles and can be targeted for therapy. Blocking these channels, like M2, NB, BM2, CM2, Vpu, p7, and 2B, may offer a lethal therapeutic strategy against serious human infections.

Area of Science:

  • Virology
  • Molecular Biology
  • Biochemistry

Background:

  • Viral ion channels are essential membrane proteins that regulate viral life cycles.
  • These channels function by altering electrochemical or proton gradients across cell membranes, influencing viral and cellular activities.
  • The viroproin family of viral channel proteins plays a role in viral functions, including particle release.

Purpose of the Study:

  • To review seven viral ion channels responsible for serious human infections.
  • To highlight the therapeutic potential of blocking these viral channel proteins.

Main Methods:

  • Literature review of viral ion channels.
  • Discussion of the mechanism of action of viral ion channels.
  • Analysis of therapeutic strategies targeting viral ion channels.

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Expression and Purification of Mammalian Bestrophin Ion Channels
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Expression and Purification of Mammalian Bestrophin Ion Channels

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Controllable Ion Channel Expression through Inducible Transient Transfection

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Author Spotlight: Exploring the Role of Ion Channels in Cancer: Characterization and Potential Treatment Approaches
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Expression and Purification of Mammalian Bestrophin Ion Channels
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Controllable Ion Channel Expression through Inducible Transient Transfection
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Controllable Ion Channel Expression through Inducible Transient Transfection

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Main Results:

  • Seven specific viral ion channels are identified: M2 (influenza A), NB and BM2 (influenza B), CM2 (influenza C), Vpu (HIV-1), p7 (HCV), and 2B (picornaviruses).
  • These channels are critical for viral replication and pathogenesis.
  • Inhibition of these channels presents a potential therapeutic approach.

Conclusions:

  • Viral ion channels are vital targets for antiviral therapies.
  • Blocking these channels can be a lethal strategy against viral infections.
  • Further research into viral ion channel inhibitors is warranted.