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08:50
Duodenal-Jejunal Bypass Surgery in Diet-Induced Obese Diabetic Mice
Published on: October 18, 2024
Surgical therapy for diabesity.
Kervin Arroyo1, Subhash U Kini, John E Harvey
1Mount Sinai School of Medicine, New York, NY, USA.
The Mount Sinai Journal of Medicine, New York
|October 21, 2010
Summary
Bariatric surgery significantly improves glycemic control in patients with type 2 diabetes mellitus, also known as diabesity. This review explores surgical options and their metabolic effects for managing this condition.
Area of Science:
- Endocrinology
- Metabolic Surgery
- Obesity Medicine
Background:
- Type 2 diabetes mellitus (T2DM) affects over 170 million globally, often linked with obesity, termed 'diabesity'.
- Bariatric surgery is established for sustained weight loss in morbid obesity.
- Postoperative glycemic control improvement is a common secondary effect of bariatric procedures.
Purpose of the Study:
- To review the literature on the efficacy of bariatric surgery for treating type 2 diabetes mellitus.
- To highlight the role of surgical interventions in managing diabesity.
Main Methods:
- Review of existing literature on bariatric surgical procedures and their impact on T2DM.
- Analysis of common and investigational surgical techniques.
Main Results:
- Bariatric procedures demonstrate remarkable improvement in glycemic control.
- Mechanisms include volume restriction, intestinal bypass, and hormonal alterations.
- Several surgical options are available, including adjustable gastric band, Roux-en-Y gastric bypass, biliopancreatic diversion with duodenal switch, and sleeve gastrectomy.
Conclusions:
- Bariatric surgery shows significant promise as a major tool for long-term T2DM management.
- Growing evidence supports the use of these operations for diabesity.
- Further research and data collection are ongoing.
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