[Indirect lymphography for diagnosis of limb lymphedema]

Twenty patients with various forms of lymphedema were studied by indirect lymphography. Isovist (Schering AG, Berlin) used for intradermal infusion is a new non-ionic, water-soluble, dimeric contrast media. It has following advantages: ideal iso-osmolarity, lowest physical-chemicotoxicity, and excellent tissue tolerance. Simultaneous indirect lymphography was recommended. Characteristic patterns of lymphatics were demonstrated. The newly developed Isovist allows visualization of initial lymphatics by intradermal infusion. However they are not displayed with direct lymphography unless in the presence of valvular insufficiency. It can be performed within 30 minutes. No chemical injury to lymphatics would happen so that this procedure could performed repeatedly.