Feminizing adrenocortical tumor. Histological and ultrastructural study

Area of Science:

• Endocrinology
• Oncology
• Pathology

Background:

• Feminizing adrenocortical tumors are rare, often presenting with hormonal imbalances like Cushing's syndrome.
• Understanding the ultrastructural characteristics of these tumors is crucial for diagnosis and prognosis.

Observation:

• A case of a 29-year-old male with a feminizing adrenocortical tumor and Cushing's syndrome is detailed.
• The tumor exhibited nuclear pleomorphism, enlarged nucleoli, and nuclear pseudoinclusions, consistent with adrenal carcinomas.
• Cytoplasmic organelles showed similarities to both feminizing and androgen-secreting adrenal tumors, with diverse mitochondria and abundant smooth endoplasmic reticulum.

Findings:

• Histological and ultrastructural features suggested potential malignancy.
• Most feminizing adrenal tumors are identified as carcinomata.
• The patient showed no local recurrence or distant metastases two years after tumor excision.

Implications:

• This case highlights the importance of detailed ultrastructural examination for diagnosing rare adrenocortical tumors.
• The findings contribute to understanding the spectrum of adrenocortical neoplasms and their malignant potential.
• Early detection and surgical intervention appear critical for favorable outcomes in these rare conditions.