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Updated: Jun 7, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
[A case of coronary stent thrombosis occurring repeatedly in the perioperative period]
Misako Higuchi1, Shigekazu Sugino, Hayato Echizenya
1Department of Anesthesia, Otaru Municipal Hospital, Otaru 047-8550.
Insights
This case report highlights a patient experiencing in-stent thrombosis after elective surgery. Early recognition and continued dual antiplatelet therapy are crucial for managing coronary stent complications.
Area of Science:
- Cardiology
- Anesthesiology
- Vascular Surgery
Background:
- A 60-year-old male with angina underwent major abdominal surgery four weeks post-coronary bare-metal stent implantation.
- Perioperative management included aspirin, clopidogrel, and heparin, with anesthesia maintained by sevoflurane, remifentanil, and fentanyl.
Observation:
- Transient ST-segment elevation occurred intraoperatively, resolving spontaneously.
- Postoperatively, significant ST-segment elevation in leads V2-V6 indicated acute cardiac events.
Findings:
- Emergent cardiac catheterization revealed in-stent thrombosis of the left anterior descending coronary artery.
- The patient experienced recurrent stent thrombosis despite additional stenting and anticoagulation.
Implications:
- This case underscores the risk of coronary stent thrombosis in the perioperative period.
- Anesthesiologists must consider stent type, surgical timing, and maintain aspirin administration to mitigate risks.
Abstract:
A 60-year-old man with angina was scheduled for total gastrectomy, splenectomy, and cholecystectomy. Bare-metal stents were implanted into his left anterior descending coronary artery four weeks before the operation. Aspirin and clopidogrel were administered until one week before the operation and then injection of to 15,000 units of heparin per day was given. Anesthesia was maintained with sevoflurane, remifentanil and fentanyl. At 330 minutes after starting the operation, 2-mm ST segment elevation was observed and it recovered immediately. After the operation, new 9-mm ST segment elevation in leads V2-V6 was observed. Emergent cardiac catheterization showed occlusion of the coronary artery with in-stent thrombosis. An additional stent was implanted and 10,000 units of heparin per day was injected. After five days, new stent thrombosis occurred and an additional stent was implanted. Administration of aspirin, clopidogrel and cilostazol was started immediately. Anesthesiologists should pay attention to the kind of coronary stent, consider the timing of the operation, and continue administration of aspirin.
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