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Haemorheology in diabetes.

T K Dutta¹, A K Das

¹Department of Medicine, JIPMER, Pondicherry.

The Journal of the Association of Physicians of India

|December 1, 1990

Summary

Diabetes disrupts blood flow (haemorheology) by increasing blood viscosity and reducing red blood cell flexibility. Fortunately, insulin treatment can reverse these harmful changes, aiding in the management of diabetic vasculopathy.

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Area of Science:

Cardiovascular Science
Endocrinology
Hematology

Background:

Diabetes mellitus is associated with significant microvascular complications.
Altered blood rheology, including increased viscosity and reduced red blood cell deformability, is a known complication of diabetes.
These rheological changes are implicated in the pathogenesis of diabetic vasculopathy.

Purpose of the Study:

To investigate the impact of diabetes on blood rheology.
To determine the relationship between altered haemorheology and diabetic vasculopathy.
To assess the reversibility of these rheological changes with insulin therapy.

Main Methods:

Blood viscosity measurements.
Red blood cell deformability assays.
Clinical assessment of diabetic vasculopathy.
Evaluation of rheological parameters before and after insulin treatment.

Main Results:

Diabetes significantly increases blood viscosity.
Red blood cells exhibit decreased deformability in diabetic patients.
These rheological abnormalities correlate with the presence and severity of diabetic vasculopathy.
Insulin treatment demonstrably improves blood viscosity and red blood cell deformability.

Conclusions:

Disturbed blood rheology is a key factor in the development of diabetic vasculopathy.
Insulin therapy can effectively reverse the detrimental effects of diabetes on blood rheology.
Targeting haemorheological parameters may offer a therapeutic strategy for managing diabetic complications.

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