Related Experiment Video
Updated: Jun 7, 2026

10:33
Primed Mycobacterial Uveitis (PMU) as a Model for Post-Infectious Uveitis
Published on: December 17, 2021
[Inaugural bilateral panuveitis in relapsing polychondritis]
B Guignier1, L Messer, A Subilia
1Service d'ophtalmologie, hôpitaux Civils de Colmar, 68000 Colmar, France. benoit.guignier@hotmail.fr
Journal Francais D'Ophtalmologie
|October 22, 2010
Summary
Relapsing polychondritis can cause rare but severe eye inflammation called uveitis. Early diagnosis is crucial to prevent vision loss in patients with this rare autoimmune condition.
Area of Science:
- Rheumatology
- Ophthalmology
Background:
- Relapsing polychondritis (RP) is a rare systemic autoimmune disease characterized by progressive cartilage destruction.
- Ocular manifestations are common in RP, but specific inflammatory eye conditions like uveitis are infrequent.
Observation:
- A 72-year-old male patient presented with bilateral panuveitis.
- The patient had a history of unclassified arthritis.
- Recurrent episodes of uveitis accompanied by ear chondritis prompted further investigation.
Findings:
- The clinical presentation led to the diagnosis of relapsing polychondritis.
- Uveitis, while a known ocular complication of RP, is considered a rare symptom.
- The diagnosis was confirmed by the characteristic association of recurrent uveitis and chondritis.
Implications:
- This case highlights the importance of considering relapsing polychondritis in patients with unexplained recurrent uveitis, especially when other characteristic symptoms like chondritis are present.
- Prompt diagnosis and management of uveitis in the context of relapsing polychondritis are essential to mitigate the risk of significant visual impairment.
- The case underscores the diverse and sometimes rare ocular manifestations of systemic autoimmune diseases.
Related Concept Videos
Pericarditis I: Introduction
Pericarditis is defined as the inflammation of the pericardium, the thin, sac-like membrane surrounding the heart. This condition can cause significant chest pain and other symptoms, often necessitating medical intervention. The pericardium has two layers: the inner visceral layer and the outer parietal layer, separated by a small amount of fluid that reduces friction during heartbeats.Types of PericarditisPericarditis can be classified into several types based on the duration and nature of the...
Chronic Pancreatitis II: Collaborative Care
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
Assessment:
Chronic Pancreatitis I: Introduction
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80% of...
Chronic Pancreatitis I: Introduction
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Chronic Pancreatitis II: Pathophysiology
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
Acute Pyelonephritis I: Introduction
Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...

