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"Designer drugs"--a current perspective.

D A Jerrard1

  • 1Department of Surgery, University of Maryland School of Medicine, Baltimore.

The Journal of Emergency Medicine
|November 1, 1990
PubMed
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Chemists created new "designer drugs" by modifying existing controlled substances to bypass regulations. This review covers their history, effects, abuse trends, and treatment.

Area of Science:

  • Forensic Chemistry
  • Pharmacology
  • Toxicology

Background:

  • Since the 1970s, clandestine labs have synthesized novel psychoactive substances.
  • These "designer drugs" are often derivatives of controlled substances like fentanyl and amphetamine.
  • They were created to circumvent the Federal Controlled Substances Act due to unique chemical structures.

Purpose of the Study:

  • To provide a comprehensive review of designer drugs.
  • To examine historical data, pharmacokinetics, and abuse trends.
  • To discuss treatment options and emerging substances.

Main Methods:

  • Literature review of scientific articles and legal documents.
  • Analysis of historical trends in drug synthesis and abuse.

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  • Examination of pharmacological data and clinical reports.

    • Main Results:

    • Designer drugs emerged in the late 1970s, exploiting legal loopholes.
    • Modified fentanyl, amphetamine, and phencyclidine derivatives became prevalent.
    • These substances pose significant public health challenges due to recreational abuse.

    Conclusions:

    • Designer drugs represent an evolving challenge in substance abuse and control.
    • Understanding their pharmacology and trends is crucial for effective treatment and prevention.
    • Continued monitoring and research are necessary to address new synthetic drug threats.