Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)00:53

Olefin Metathesis Polymerization: Acyclic Diene Metathesis (ADMET)

Acyclic diene metathesis polymerization or ADMET polymerization involves cross-metathesis of terminal dienes, such as 1,8-nonadiene, to give linear unsaturated polymer and ethylene. As ADMET is a reversible process, the formed ethylene gas must be removed from the reaction mixture to complete the polymerization process.
Similar to cross-metathesis, ADMET also involves the formation of metallacyclobutane intermediate by [2+2] cycloaddition of one of the double bonds of a terminal diene with...
Leaky Scanning02:28

Leaky Scanning

During most eukaryotic translation processes, the small 40S ribosome subunit scans an mRNA from its 5' end until it encounters the first start AUG codon. The large 60S ribosomal subunit then joins the smaller one to initiate protein synthesis. The location of the translation initiation is largely determined by the nucleotides near the start codon as there may be multiple translation initiation sites present on the mRNA.  Marilyn Kozak discovered that the sequence RCCAUGG (where R stands for...
Phase I Reactions: Reductive Reactions01:27

Phase I Reactions: Reductive Reactions

Phase I biotransformation reductive reactions are chemical processes that modify drugs by introducing or revealing polar functional groups via reduction. Enzymes called reductases catalyze these reactions, playing a pivotal role in drug metabolism by transforming lipophilic drugs into more polar, water-soluble metabolites for easy excretion. An essential type of reductive reaction is the carbonyl group reduction, where aldehydes and ketones are reduced to alcohols. An example is the...
Olefin Metathesis Polymerization: Overview01:13

Olefin Metathesis Polymerization: Overview

Recently, the development of olefin metathesis polymerization advanced the field of polymer synthesis. Simply put, the reorganization of substituents on their double bonds between two olefins in the presence of a catalyst is known as the olefin metathesis reaction. The use of metathesis reaction for polymer synthesis is called olefin metathesis polymerization.
Ruthenium-based Grubbs catalyst is the most commonly used catalyst for olefin metathesis polymerization. Grubbs catalyst consists of a...
tRNA Activation02:26

tRNA Activation

Aminoacyl-tRNA synthetases are present in both eukaryotes and bacteria. Though eukaryotes have 20 different aminoacyl-tRNA synthetases to couple to 20 amino acids, many bacteria do not have genes for all of these aminoacyl-tRNA synthetases. Despite this, they still use all 20 amino acids to synthesize their proteins. For instance, some bacteria do not have the gene encoding the enzyme that couples glutamine with its partner tRNA. In these organisms, one enzyme adds glutamic acid to all of the...
Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)01:30

Nucleophilic Aromatic Substitution: Addition–Elimination (SNAr)

Nucleophilic substitution in aromatic compounds is feasible in substrates bearing strong electron-withdrawing substituents positioned ortho or para to the leaving group. The reaction proceeds via two steps: the addition of the nucleophile and the elimination of the leaving group.
The reaction begins with an attack of the nucleophile on the carbon that holds the leaving group. This results in the delocalization of the π electrons over the ring carbons. The resonance interaction between the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-scale data improves performance of machine learning model for long COVID identification.

Communications medicine·2026
Same author

Governing real-world health data as a public utility.

Science (New York, N.Y.)·2026
Same author

LinkML: an open data modeling framework.

GigaScience·2025
Same author

Development of a robust corpus for automated evaluation of online health information in Chinese using the DISCERN scale.

Journal of the American Medical Informatics Association : JAMIA·2025
Same author

Advancing the science of genomic learning healthcare systems.

Learning health systems·2025
Same author

Mondo: integrating disease terminology across communities.

Genetics·2025
Same journal

Digital divide in clinical and operational artificial intelligence adoption and implementation stages: US hospital diffusion patterns and AI deserts.

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

Extending the fundamental theorem of biomedical informatics: a proposal and illustrative examples.

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

Human factors methods for designing safe health information technology: what do the experts think?

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

Equity-by-design for socially assistive robots as digital health tools.

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

Orchestrator multi-agent clinical decision support system for secondary headache diagnosis in primary care.

Journal of the American Medical Informatics Association : JAMIA·2026
Same journal

CUI-Curate: a GraphRAG-based framework for automated clinical concept curation for NLP applications.

Journal of the American Medical Informatics Association : JAMIA·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2026

Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites
05:28

Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites

Published on: June 2, 2023

Comparing and evaluating terminology services application programming interfaces: RxNav, UMLSKS and LexBIG.

Jyotishman Pathak1, Lee Peters, Christopher G Chute

  • 1Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, Minnesota 55905, USA. pathak.jyotishman@mayo.edu

Journal of the American Medical Informatics Association : JAMIA
|October 22, 2010
PubMed
Summary
This summary is machine-generated.

This study evaluated three terminology services APIs: RxNav, UMLSKS, and LexBIG, for accessing RxNorm data. Findings revealed implementation and documentation issues, leading to improvements in these biomedical terminology APIs.

More Related Videos

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Related Experiment Videos

Last Updated: Jun 7, 2026

Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites
05:28

Monitoring On-Target Signaling Responses in Larval Zebrafish - Z-REX Unmasks Precise Mechanisms of Electrophilic Drugs and Metabolites

Published on: June 2, 2023

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System
05:10

Drug Repurposing Hypothesis Generation Using the "RE:fine Drugs" System

Published on: December 11, 2016

Area of Science:

  • Biomedical Informatics
  • Health Informatics
  • Computer Science

Background:

  • Terminology services APIs are crucial for integrating biomedical terminologies into applications.
  • RxNorm is a key standard for மருந்துக் (drug) terminology.
  • Evaluating API performance is essential for reliable data integration.

Observation:

  • Three prominent APIs (RxNav, UMLSKS, LexBIG) were assessed for their ability to retrieve information from RxNorm.
  • A comprehensive query set tested functionalities like concept retrieval and relationship navigation.
  • Test data derived from the RxNorm dataset was used for evaluation.

Findings:

  • Issues were identified in API implementation, including LexBIG's handling of obsolete terms.
  • Documentation discrepancies, such as navigational paths in RxNav, were also noted.
  • These identified issues prompted subsequent improvements by the respective API development teams.

Implications:

  • Understanding API discrepancies aids developers in selecting appropriate tools for specific use cases.
  • Improved API functionality enhances the integration of biomedical terminologies.
  • This evaluation contributes to the advancement of health informatics standards and practices.