Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Redox Reactions01:24

Redox Reactions

Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
Oxidations of Aldehydes and Ketones to Carboxylic Acids01:15

Oxidations of Aldehydes and Ketones to Carboxylic Acids

Oxidation of aldehydes and ketones results in the formation of carboxylic acids. Aldehydes, bearing hydrogen next to the carbonyl group, are easily oxidized compared to ketones. This is because an aldehydic proton can easily be abstracted during oxidation.
Aldehydes readily undergo oxidation in strong oxidizing agents such as potassium permanganate and chromic acid. The oxidation can also be carried out using mild oxidizing agents such as silver oxide. In fact, aldehydes can be easily oxidized...
Washing, Drying, and Ignition of Precipitates00:52

Washing, Drying, and Ignition of Precipitates

After filtration, the precipitate is washed to remove coprecipitated impurities and any remaining mother liquor. Colloidal precipitates, such as silver chloride, are washed with an electrolyte (such as dilute nitric acid) to prevent the peptization of the precipitate. In the case of slightly soluble precipitates, the wash solution contains a common ion to reduce solubility. Lead sulfate, which is slightly soluble in water, is washed with dilute sulfuric acid. Similarly, wash solutions may be...
Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate02:21

Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate

Alkenes can be dihydroxylated using potassium permanganate. The method encompasses the reaction of an alkene with a cold, dilute solution of potassium permanganate under basic conditions to form a cis-diol along with a brown precipitate of manganese dioxide.
Extraction: Advanced Methods00:56

Extraction: Advanced Methods

Metal ions can be separated from one another by complexation with organic ligands–the chelating agent– to form uncharged chelates. Here, the chelating agent must contain hydrophobic groups and behave as a weak acid, losing a proton to bind with the metal. Since most organic ligands used in this process are insoluble or undergo oxidation in the aqueous phase, the chelating agent is initially added to the organic phase and extracted into the aqueous phase. The metal-ligand complex is formed in...
Oxidative Cleavage of Alkenes: Ozonolysis01:46

Oxidative Cleavage of Alkenes: Ozonolysis

In ozonolysis, ozone is used to cleave a carbon–carbon double bond to form aldehydes and ketones, or carboxylic acids, depending on the work-up.
Ozone is a symmetrical bent molecule stabilized by a resonance structure.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The use of highly crosslinked polyethylene in total knee arthroplasty.

The bone & joint journal·2017
Same author

In vivo oxidation in retrieved highly crosslinked tibial inserts.

Journal of biomedical materials research. Part B, Applied biomaterials·2012
Same author

Delamination of a highly cross-linked polyethylene liner associated with titanium deposits on the cobalt-chromium modular femoral head following dislocation.

The Journal of bone and joint surgery. British volume·2010
Same author

Effect of fabrication method and resin type on performance of tibial bearings.

Journal of biomedical materials research·2000
Same author

Current sterilization and packaging methods for polyethylene.

Clinical orthopaedics and related research·1999
Same author

The impact of sterilization method on wear in knee arthroplasty.

Clinical orthopaedics and related research·1999

Related Experiment Video

Updated: Jun 7, 2026

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
07:16

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation

Published on: June 21, 2021

In vivo oxidation in remelted highly cross-linked retrievals.

B H Currier1, D W Van Citters, J H Currier

  • 1Thayer School of Engineering, Dartmouth College, 8000 Cummings Hall, Hanover, NH 03755, USA. barbara.h.currier@dartmouth.edu

The Journal of Bone and Joint Surgery. American Volume
|October 22, 2010
PubMed
Summary
This summary is machine-generated.

Highly cross-linked ultra-high molecular weight polyethylene (UHMWPE) shows unexpected oxidation in vivo. Retrieved implants revealed oxidation after two years, contradicting expected stability and shelf-storage behavior. Further research is needed.

More Related Videos

Enabling Real-Time Compensation in Fast Photochemical Oxidations of Proteins for the Determination of Protein Topography Changes
07:38

Enabling Real-Time Compensation in Fast Photochemical Oxidations of Proteins for the Determination of Protein Topography Changes

Published on: September 1, 2020

Original Experimental Approach for Assessing Transport Fuel Stability
09:48

Original Experimental Approach for Assessing Transport Fuel Stability

Published on: October 21, 2016

Related Experiment Videos

Last Updated: Jun 7, 2026

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
07:16

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation

Published on: June 21, 2021

Enabling Real-Time Compensation in Fast Photochemical Oxidations of Proteins for the Determination of Protein Topography Changes
07:38

Enabling Real-Time Compensation in Fast Photochemical Oxidations of Proteins for the Determination of Protein Topography Changes

Published on: September 1, 2020

Original Experimental Approach for Assessing Transport Fuel Stability
09:48

Original Experimental Approach for Assessing Transport Fuel Stability

Published on: October 21, 2016

Area of Science:

  • Biomaterials Science
  • Orthopedic Engineering
  • Polymer Chemistry

Background:

  • Oxidation prevention is key for advanced ultra-high molecular weight polyethylene (UHMWPE) in joint replacements.
  • Highly cross-linked UHMWPE aims to improve oxidative stability and product longevity.
  • Remelted UHMWPE materials are a focus for enhanced bearing performance.

Purpose of the Study:

  • To evaluate oxidation in retrieved, remelted, highly cross-linked UHMWPE joint replacement bearings.
  • To compare in vivo oxidation of retrieved UHMWPE with shelf-stored controls.
  • To test the hypothesis that in vivo oxidative stability matches shelf-storage stability.

Main Methods:

  • Analysis of retrieved remelted UHMWPE acetabular liners and tibial inserts (n=69) using Fourier transform infrared spectroscopy.
  • Examination of shelf-stored UHMWPE liners (n=3) for free radical content (electron paramagnetic resonance) and oxidation (FTIR).
  • Comparison of oxidation levels in retrieved implants (in vivo for ≥2 years) versus controls (shelf-aged 8-9 years).

Main Results:

  • Shelf-stored UHMWPE controls exhibited no measurable free radicals or oxidation.
  • Measurable oxidation was detected in 22% of retrieved remelted UHMWPE implants.
  • Oxidation occurred in retrieved implants after an average of two years in vivo.

Conclusions:

  • Remelted highly cross-linked UHMWPE was expected to be oxidation-resistant in vivo based on control data.
  • Observed in vivo oxidation in some retrieved UHMWPE implants challenges this expectation.
  • Continued investigation into in vivo oxidation mechanisms of UHMWPE is warranted.