Related Experiment Videos
Canaloplasty for primary open-angle glaucoma: long-term outcome
Matthias C Grieshaber1, Ané Pienaar, Jan Olivier
1Department of Ophthalmology, Medical University of Southern Africa, MEDUNSA, Pretoria, South Africa. mgrieshaber@uhbs.ch
The British Journal of Ophthalmology
|October 22, 2010
Summary
Canaloplasty effectively lowers intraocular pressure in Black African patients with primary open-angle glaucoma. This bleb-independent procedure offers a safe, long-term alternative to traditional glaucoma surgery.
Area of Science:
- Ophthalmology
- Glaucoma Research
- Surgical Innovation
Background:
- Primary open-angle glaucoma (POAG) is a leading cause of irreversible blindness, particularly in African populations.
- Current treatments often involve incisional surgery with potential complications.
Purpose of the Study:
- To evaluate the safety and efficacy of 360° viscodilation and tensioning of Schlemm's canal (canaloplasty) in Black African patients with POAG.
- To assess long-term intraocular pressure (IOP) reduction and complication rates.
Main Methods:
- A prospective study included 60 eyes of 60 consecutive POAG patients.
- Canaloplasty involved 360° catheterization of Schlemm's canal using a microcatheter and a tensioning suture.
- Follow-up extended to 36 months, with IOP measurements at regular intervals.
Main Results:
- Mean preoperative IOP was 45.0 ± 12.1 mm Hg, significantly reduced post-procedure.
- At 36 months, mean IOP was 13.3 ± 1.7 mm Hg.
- Complete and qualified success rates for IOP ≤ 21 mm Hg were 77.5% and 81.6%, respectively.
- Low complication rates were observed, including Descemet's detachment and elevated IOP.
Conclusions:
- Canaloplasty provides sustained IOP reduction in Black African POAG patients, irrespective of initial IOP.
- As a bleb-independent procedure, it presents a viable alternative to conventional filtering surgery.
- It is particularly suitable for patients prone to enhanced wound healing and scar formation.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
01:27Open Angle Glaucoma: Treatment
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
01:25Glaucoma: Overview
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...