Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Peripheral Artery Disease I: Introduction

Peripheral Artery Disease I: Introduction

Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...

Atherosclerosis I: Introduction

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Bone Disorders

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Disparities in Heart Transplantation Allocation and Outcomes by Blood Type in Korea (2010-2022).

Korean circulation journal·2025

Same author

Electrocardiographic-Driven artificial intelligence Model: A new approach to predicting One-Year mortality in heart failure with reduced ejection fraction patients.

International journal of medical informatics·2025

Same author

J-shaped relationship between serum creatinine and mortality in Korean patients with acute heart failure.

Clinical research in cardiology : official journal of the German Cardiac Society·2024

Same author

Eligibility and Cost-Utility Analysis of Dapagliflozin in Patients with Heart Failure Across the Whole Spectrum of Ejection Fraction in South Korea.

American journal of cardiovascular drugs : drugs, devices, and other interventions·2024

Same author

Metformin treatment is associated with improved survival in diabetic patients hospitalized with acute heart failure: A prospective observational study using the Korean acute heart failure registry data.

Diabetes & metabolism·2023

Same author

Artificial intelligence assessment for early detection of heart failure with preserved ejection fraction based on electrocardiographic features.

European heart journal. Digital health·2023

Search research articles

Related Experiment Video

Updated: Jun 7, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Aging and arterial stiffness.

Hae-Young Lee¹, Byung-Hee Oh

¹Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.

Circulation Journal : Official Journal of the Japanese Circulation Society

|October 22, 2010

Summary

Arterial stiffening with age involves wall thickening and reduced elasticity, increasing cardiovascular disease risk. Managing hypertension can help prevent or delay vascular aging.

Area of Science:

Cardiovascular Science
Gerontology
Vascular Biology

Background:

Arterial walls undergo significant changes with age, including luminal enlargement, wall thickening, and reduced elasticity in large elastic arteries.
Chronic arterial pulsation leads to elastin fiber fatigue and fracture, while vascular calcification and endothelial dysfunction are hallmarks of arterial aging.
These age-related arterial changes increase pulse wave velocity, systolic blood pressure, and pulse pressure.

Purpose of the Study:

To review the physiological changes associated with vascular aging.
To discuss the impact of cardiovascular risk factors on accelerating vascular aging.
To highlight the role of vascular aging as an independent risk factor for cardiovascular diseases and target organ damage.

Main Methods:

More Related Videos

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Related Experiment Videos

Last Updated: Jun 7, 2026

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Measuring the Stiffness of Ex Vivo Mouse Aortas Using Atomic Force Microscopy

Published on: October 19, 2016

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Measuring Ascending Aortic Stiffness In Vivo in Mice Using Ultrasound

Published on: December 2, 2014

Literature review of established changes in arterial structure and function with age.
Analysis of the contribution of risk factors like hypertension, metabolic syndrome, and diabetes to vascular aging.
Examination of the link between vascular aging and cardiovascular outcomes such as atherosclerosis, stroke, and heart failure.

Main Results:

Vascular aging is characterized by reduced arterial elasticity, increased stiffness, and calcification, leading to elevated blood pressure and pulse wave velocity.
Cardiovascular risk factors significantly accelerate the process of vascular aging.
Vascular aging is a critical independent predictor of various cardiovascular diseases and associated target organ damage.

Conclusions:

Vascular aging is a complex process involving structural and functional arterial changes that increase cardiovascular risk.
Interventions targeting cardiovascular risk factors, particularly hypertension control, are crucial for mitigating vascular aging.
Preventing or delaying vascular aging is essential for reducing the burden of cardiovascular disease.