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06:08
A Novel Method: Super-selective Adrenal Venous Sampling
Published on: September 15, 2017
Primary bilateral adrenal diffuse large B-cell lymphoma demonstrating adrenal failure
Kazuhiko Horiguchi1, Koshi Hashimoto, Masayuki Hashizume
1Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi.
Internal Medicine (Tokyo, Japan)
|October 22, 2010
Summary
Primary adrenal lymphoma (PAL) is a rare condition. This case highlights PAL as a potential cause of adrenal insufficiency in patients with bilateral adrenal tumors.
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Primary adrenal lymphoma (PAL) is exceptionally rare, distinct from secondary adrenal involvement by lymphoma.
- Malignant lymphoma infiltration of the adrenal glands is more common than primary adrenal lymphoma.
Observation:
- A 58-year-old male presented with bilateral adrenal masses and subsequent adrenal insufficiency.
- Computed tomography-guided needle biopsy confirmed primary large B-cell lymphoma of the adrenal glands.
Findings:
- The patient achieved initial complete remission with combination chemotherapy and rituximab.
- Disease recurrence manifested as brain metastasis, ultimately leading to the patient's death.
Implications:
- PAL should be considered in the differential diagnosis of bilateral adrenal incidentalomas presenting with progressive adrenal insufficiency.
- This case underscores the aggressive nature of PAL and the importance of early recognition.
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