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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
Published on: July 29, 2014
[Analgesic therapy of calciphylaxis with levomethadone : a case study]
M Poels1, R Joppich, K Gerbershagen
1Klinik für Anästhesiologie und Operative Intensivmedizin, Krankenhaus Merheim, Klinikum der Privaten Universität Witten/Herdecke, Ostmerheimerstr. 200, 51109 Köln, Deutschland. poelsm@kliniken-koeln.de
Abstract:
Calciphylaxis, or calcific uremic arteriopathy, is a rare complication of end-stage renal impairment. It is characterized by calcification of arterioles and development of intensely painful subcutaneous ischemic ulcerations. While symptomatic management is the mainstay of treatment, particular emphasis is placed on adequate analgesia. Conventional analgesic concepts have mostly proved to be insufficient which increases the extreme suffering of patients. This case report describes the successful analgesic treatment of calciphylaxis with levomethadone.
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