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Updated: Jun 7, 2026

FISH for Pre-implantation Genetic Diagnosis
Published on: February 23, 2011
A familial reciprocal translocation t(1;15) in three generations identified in a regular trisomy 21 patient
C García-Delgado1, E Bahena-Martínez, A Aparicio-Onofre
1Hospital Infantil de México Federico Gómez, Departamento de Genética.
Abstract:
The concurrence of a reciprocal translocation and an aneuploidy represent a rare coincidence and an interchromosome effect between these two events has been suggested. We report the case of a family with a t(1;15) in three generations which was identified through the evaluation ofa patient with classical trisomy 21 or Down syndrome. The cytogenetic analysis with GTG banding showed that the proband had a regular trisomy 21 and a balanced translocation t(1;15). FISH and microsatellite analysis were carried out in the family in order to discard an interchromosomal effect. The implications for genetic assessment are discussed.
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