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Analytical approaches for an important shellfish poisoning agent: domoic Acid
Yu He1, Agnes Fekete, Guonan Chen
1Key Laboratory of Analysis and Detection for Food Safety, Ministry of Education, Fuzhou University, Fuzhou, Fujian 350002, People's Republic of China.
Journal of Agricultural and Food Chemistry
|October 23, 2010
Summary
Domoic acid (DA), a marine toxin from phytoplankton, causes amnesic shellfish poisoning in humans. This review covers DA
Area of Science:
- Marine biology
- Neurotoxicology
- Analytical chemistry
Background:
- Domoic acid (DA) is a neurotoxin produced by phytoplankton.
- It causes amnesic shellfish poisoning (ASP) in humans.
- DA accumulation in shellfish poses a significant public health risk.
Purpose of the Study:
- To summarize the toxicology of domoic acid.
- To review the chemistry of domoic acid.
- To present an overview of analytical methods for DA determination.
Main Methods:
- Literature review of toxicology, chemistry, and analytical methods for DA.
- Discussion of various detection assays including bioassays, immunoassays, liquid chromatography, capillary electrophoresis, and capillary electrochromatography.
Main Results:
- DA induces neuronal degeneration, particularly in the hippocampus.
- Various analytical techniques exist for DA detection in diverse matrices like shellfish, algae, and seawater.
- Liquid chromatography is a commonly reported method.
Conclusions:
- Understanding DA toxicology and chemistry is crucial for public health.
- Accurate and sensitive methods for DA determination are essential for food safety.
- Continued development and application of analytical techniques are necessary to monitor DA contamination.
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