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Protein lysine acetylation in cellular function and its role in cancer manifestation

Mohammed Arif1, Parijat Senapati, Jayasha Shandilya

  • 1Transcription and Disease Laboratory, Molecular Biology and Genetics Unit, Jawaharlal Nehru Centre for Advanced Scientific Research, Jakkur (P.O.), Bangalore-560 064, Karnataka, India.

Biochimica Et Biophysica Acta
|October 23, 2010
PubMed

Insights

Protein lysine acetylation is vital for cell functions like DNA processes and metabolism. Its dysfunction is linked to diseases, particularly cancer, highlighting its critical role in disease manifestation.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Lysine acetylation regulates numerous cellular processes, including DNA replication, metabolism, and cell signaling.
  • The cellular acetylome, comprising acetylated proteins, is extensive and dynamically regulated.
  • Protein acetylation interacts with other post-translational modifications, influencing protein function.

Purpose of the Study:

  • To review recent advancements in understanding protein lysine acetylation.
  • To explore the role of acetylation in various cellular functions.
  • To discuss the implications of acetylation dysfunction in cancer.

Main Methods:

  • Literature review of recent research on protein lysine acetylation.
  • Analysis of studies investigating acetylation's role in cellular processes.
  • Examination of evidence linking acetylation to cancer development.

Main Results:

  • Lysine acetylation is essential for fundamental biological activities.
  • Dysregulation of acetylation is implicated in the pathogenesis of several diseases, notably cancer.
  • The interplay between acetylation and other modifications fine-tunes cellular machinery.

Conclusions:

  • Protein lysine acetylation is a critical post-translational modification with broad cellular functions.
  • Aberrant acetylation processes are significantly associated with cancer.
  • Further research into acetylation mechanisms may offer therapeutic strategies for cancer.

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